While great strides have been made to better understand the molecular underpinnings of gene regulatory psm-mec-dependent mechanisms in S. aureus pathogenesis, in the future the focus should be shifted toward the investigation of how the psm-mec locus affects the pathogenesis in other Staphylococcus species, especially S. epidermidis and S. haemolyticus, which, alongside S. aureus, are the most frequent and pathogenic agents of hospital-associated infections around the world. Here, CCL28 is linked to infection.