ACHE and Alzheimer disease: The acceleration of Aβ aggregation by the peripheral site of AChE has long been recognized (Inestrosa et al., 1996; Reyes et al., 1997) and is an important component of effective AChE inhibitors designed to combat AD (Bartolini et al., 2003; Anand and Singh, 2013; Bolea et al., 2013; Bautista-Aguilera et al., 2014a; Hebda et al., 2016).