NFKB1 and central nervous system cancer: On the other hand, protection of C. parvum-primed mice from LPS lethality and diminished NF-kB activity in TLR2 ligand-stimulated glioma cells are mediated through the CB1 receptor [105, 114], whereas both cannabinoid receptors participate in decreasing cytokine levels after in vivo LPS administration [112].