UCHL5 and bacterial infectious disease: Bacterial infection can induce inflammasome activation in the host cell [36] and deubiquitination has been implicated in this process. Salmonella Typhimurium infection leads to changes in the activity of several host DUBs, such as USP4, USP5, UCHL3, and UCHL5, and increased activity of UCHL5 was found to contribute to the inflammasome activation during this infection [66].