PRSS27 and Machado-Joseph disease: There are four thiol protease families, the ubiquitin-specific proteases (USP), ubiquitin C-terminal hydrolases (UCH), ovarian tumour domain containing proteases (OTU), and Machado Joseph disease (MJD)/Josephin domain DUBs, and one zinc-metalloprotease group, the JAB1/MPN/Mov34 metalloenzyme family [2].