A20 mutations are strongly linked to autoimmunity, lymphomas, and asthma [74, 75], highlighting important differences to CYLD despite both targeting NF-κB. This might be explained by different chain preference, K48 and K11 for A20 compared to the K63 and M1 chain preference showed by CYLD [68]. Here, TNFAIP3 is linked to Autoimmunity.