2009). Low‐serum CRISPLD2 level may predict a poor outcome in patients with sepsis or septic shock (Wang et al. 2013). CRISPLD2 knockdown increased IL‐6 and IL‐8 levels in airway smooth muscle cells induced by IL‐1β (Himes et al. 2014). The gene discussed is CRISPLD2; the disease is Sepsis.