IL6 and asthma: 1999; Himes et al. 2014). More recently, using RNA‐seq profiling, we (STW) identified CRISPLD2 as a GC‐responsive gene that modulates cytokine function in airway smooth muscle cells (ASM) (Himes et al. 2014). In a search for the mechanism of action of GC‐responsive genes that suppress inflammation in asthma, Himes et al. identified CRISPLD2 as a GC target. CRISPLD2 expression was also induced by IL‐1β and siRNA‐mediated knockdown of CRISPLD2 increased IL‐1β induced expression of IL‐6 and IL‐8 in ASM cells (Himes et al. 2014).