1999; Himes et al. 2014). More recently, using RNA‐seq profiling, we (STW) identified CRISPLD2 as a GC‐responsive gene that modulates cytokine function in airway smooth muscle cells (ASM) (Himes et al. 2014). In a search for the mechanism of action of GC‐responsive genes that suppress inflammation in asthma, Himes et al. identified CRISPLD2 as a GC target. CRISPLD2 expression was also induced by IL‐1β and siRNA‐mediated knockdown of CRISPLD2 increased IL‐1β induced expression of IL‐6 and IL‐8 in ASM cells (Himes et al. 2014). This evidence concerns the gene IL1B and asthma.