The fold change of gene expression in HLF CRISPLD2siRNA over HLF NCsiRNA (same cell) were measured as shown in Figure 4B. Knockdown of endogenous CRISPLD2 significantly increased mRNA expression of proinflammatory mediators IL‐8, CCL‐2, and IL‐6, in both normal and COPD adult lung fibroblast (4 normal and 4 COPD), revealing that CRISPLD2 has intrinsic antiinflammatory properties, reducing production of proinflammatory cytokines. Here, CRISPLD2 is linked to chronic obstructive pulmonary disease.