ZFP36 and arthritic joint disease: This conclusion is based on the observations that: (1) TTP expression was higher in inflamed than non-inflamed synovial tissue (figure 1A, B); (2) strong expression coincided with activation of the MAPK p38 pathway (figure 1F); (3) precise, genetically mediated blockade of MAPK p38-dependent phosphorylation of TTP powerfully protected mice against experimental arthritis (figures 3, –5).