Although a comprehensive assessment of the molecular and behavioural changes after pharmacological NMDA receptor blockade was beyond the scope of our study, the NeuroDam findings presented here suggest that alterations in spatial genome architectures at the site of key genes implicated in the cortical dysfunction of schizophrenia, including Gad1 and Gad2 GABA synthesis genes, could occur early in the disease process (Fig. 4c,d). Here, GAD2 is linked to schizophrenia.