These target genes might have significant roles in progression of diseases since they function in remodeling of extracellular matrix (MMP9, PLAUR and SERPINE1)36, muscle formation and maintenance and tumor suppressor (DMD)37, 38, 39, tumor growth and metastasis (CXCL12) 37, 38, 40, cell shape and motility (WASF3)41 and regulation of circadian clock (KIAA1737). Here, CLOCK is linked to neoplasm.