The top list of regulator genes are enriched for cancer-related genes including TGFB1 (P = 9.20 × 10−29)18, TNF (P = 1.43 ×  × 10−21)19, TP53 (P = 1.83 × 10−21)20 and ER (P = 1.15 × 10−18)21, supporting the biological functions of the differentially expressed mRNAs relevant to breast cancer. The gene discussed is TNF; the disease is breast carcinoma.