Interestingly, though proteins such as Glyoxalase I (GLO1, DD = 3), Nitric Oxide Synthase (NOS1, DD = 3), Matrix metalloproteinase-9 (MMP9, DD = 2) and Acetylcholinesterase (ACHE, DD = 2) do not have high topological properties, they are all the therapeutic targets of stomach diseases. The gene discussed is MMP9; the disease is stomach disorder.