ZEB1 and melanoma: To further investigate the functions of ZEB1 in the modulation of melanoma cell plasticity and resistance to MAPKi, we selected two ZEB1high/MITFlow human melanoma cell lines (A375 and SKMEL5), two ZEB1low/MITFhigh short‐term cultures (C‐09.10 and GLO), and one ZEB1low/MITFhigh cell line (501MEL) (Fig 1B).