To further explore the relation between activation of RAAS and vascular complications in diabetes we analyzed the association between plasma renin levels and markers of atherosclerosis, arterial stiffness and endothelial dysfunction in 1500 subjects with and without T2D matched for age, gender and prevalence of CVD participating in the SUMMIT (SUrrogate markers for Micro- and Macro-vascular hard endpoints for Innovative diabetes Tools) study. The gene discussed is REN; the disease is type 2 diabetes mellitus.