In African American children, multivariable analysis indicated that three SNPs in the CELF2 gene (rs7068124, rs3814634, rs10905928; odds ratio (OR) = 4.28, 2.95, and 2.66, respectively) and two SNPs in the TIA1 gene (rs25921789, rs13402990; OR = 3.70 and 5.42, respectively) were significantly associated with development of ARDS (Table 3). This evidence concerns the gene TIA1 and acute respiratory distress syndrome.