3-(4, 5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sul-fophenyl) -2H-tetrazolium, inner salt (MTS) assay (Fig. 2b,f) and Annexin V apoptosis detection (Fig. 2c,g) demonstrated that the proliferation and apoptosis of miR-21-5p mimic transfected keratinocytes in both keloid and normal skin groups did not show significant changes compared with the cells transfected with the negative controls (P > 0.05). Here, ANXA5 is linked to keloid.