In non-L haplotype cohort, further multivariate analysis after adjusting for gender, age and ALT showed that patients with GC genotype of PNPLA3 locus are twice more likely to have NASH as compared to those with genotype CC (OR 2.66: 95 % CI 1.43 – 4.95). The gene discussed is GPT; the disease is metabolic dysfunction-associated steatohepatitis.