In non-L haplotype cohort, further multivariate analysis after adjusting for gender, age and ALT showed that patients with GC genotype of PNPLA3 locus are twice more likely to have NASH as compared to those with genotype CC (OR 2.66: 95 % CI 1.43 – 4.95). This evidence concerns the gene PNPLA3 and metabolic dysfunction-associated steatohepatitis.