Indeed, n-6 PUFAs have been shown to promote tumorigenesis via increasing circulating estrogenic compounds levels13, cell proliferation rate37, and inflammation38, while n-3 PUFAs have been shown to be responsible for suppressing tumor growth by decreasing circulating estrogenic compound levels13, breast cancer cell growth39, and HER2 expression40. The gene discussed is ERBB2; the disease is breast carcinoma.