ERBB2 and breast carcinoma: Another important future direction is to consider the heterogeneity of breast cancer and take the following factors into account in the measurement of PUFA levels: age, diet, lipid profile (low-density lipoproteins, high-density lipoproteins, and cholesterol levels), menopausal status, HER2 status, and use of hormonal methods of birth control including oral contraceptives or hormone-delivery skin patches.