CHEK2 and breast carcinoma: The evidence that CHEK2 is a breast cancer susceptibility gene is largely based on studies of protein truncating variants, in particular CHEK2 1100delC.33 Reports of the association of the missense variant I157T, (C15) and breast cancer risk have been conflicting but a large meta-analysis involving 15 985 breast cancer cases and 18 609 controls estimated a modest OR of 1.58 (95% CI 1.42 to 1.75).34 We also found evidence (p=0.015) of an association for c.538C>T (Align-GVGD C25); OR 1.34 (95% CI 1.06 to 1.70), a risk comparable to I157T.