In contrast, we found no evidence of an association with risk of prostate or ovarian cancer with any of these three variants: however, the confidence limits were wide; based on the upper 95% confidence limit we could exclude an OR of >1.4 for prostate cancer for the loss-of-function PALB2 c.3113G>A and 1.9 for c.1592delT and c.3113G>A combined. The gene discussed is PALB2; the disease is ovarian cancer.