CHEK2 c.1343T>G (p.Ile448Ser) was observed in 35 cases and 11 controls, all African, participating in PRACTICAL and was also associated with an increased risk of prostate cancer (OR 3.03 (95% CI 1.53 to 6.03, p=0.00059)). Here, CHEK2 is linked to prostate carcinoma.