CHEK2 and ovarian cancer: None of the above four CHEK2 variants (CHEK2 c.349A>G (p.Arg117Gly); c.538C>T (p.Arg180Cys); c.715G>A (p.Glu239Lys) and c.1036C>T (p.Arg346Cys)) were found to be associated with an increased risk of prostate or ovarian cancer (tables 3 and 4).