Consistent with previous reports,5–7, 9, 11–13PALB2 c.3113G>A (p.Trp1038*), PALB2 c.1592delT (p.Leu531Cysfs) and ATM c.7271T>G (p.Val2424Gly) were found to be associated with substantially increased risk of breast cancer all with associated relative risk estimates of 3.44 or greater. This evidence concerns the gene PALB2 and breast cancer.