Our data indicate a potential key role for these peptides in cellular interactions and thus suggests the exciting possibility of using surface protein‐derived peptide loops as potential anti‐adhesive therapeutics or immunization antigens (as has been used for other P. gingivalis proteins (Cai, Kurita‐Ochiai, Kobayashi, Hashizume, & Yamamoto, 2013)) but also OmpA as a potential drug target for treatment of periodontal disease via targeting the keystone pathogen, P. gingivalis. The gene discussed is CA1; the disease is periodontal disorder.