One such Nab, recombinant human monoclonal IgM antibody (rHIgM22) that specifically binds to live oligodendrocytes and myelin was recently evaluated in a 16-site phase 1 clinical trial [31] in 72 MS patients, with demonstration of the safety of antibody at all dose increments. The gene discussed is CD40LG; the disease is myeloid sarcoma.