It was reported that DcR3 concentrations were increased in patients with primary biliary cirrhosis in both local and systemic levels when compared to healthy controls [21], while researchers from Japan suggest that sDcR3 values may be helpful in differentiating between active and inactive chronic hepatitis B in the subgroup of hepatitis B e antigen-negative patients [22]. Here, TNFRSF6B is linked to primary biliary cholangitis.