PTGES and myocardial infarction: Degousee et al. showed that, twenty-eight days after MI, mPGES-1 KO mice developed more severe pathological left ventricle (LV) remodeling compared to WT, including eccentric cardiomyocyte hypertrophy, impaired LV systolic and diastolic function, LV dilation, and elevated LV end-diastolic pressure [15].