Moreover, NDUFC2 appears downregulated in skeletal muscle cells of subjects affected by insulin resistance [69] and it is associated with insulin secretion in vivo [70]. Ndufc2 expression is induced under Bendavia treatment, a novel molecule able to counteract mitochondrial dysfunction, in the noninfarcted border zone within the rat heart, underscoring a key role of a regular complex I activity in ischemic heart disease [71]. Here, NDUFC2 is linked to Insulin resistance.