Nevertheless, the finding that altered methylation of CpGs within the promoter of ANRIL, a long non-coding RNA previously linked to CHD risk through GWAS, is associated with predictors of CHD risk in childhood suggest that differential methylation of this region maybe a marker which could be used to identify those individuals at increased risk of CHD in early life. This evidence concerns the gene CDKN2B-AS1 and coronary artery disorder.