Engineered human umbilical cord mesenchymal stem cells (HUMSCs) to secrete soluble TRAIL via adenoviral transduction mediated by cell-permeable peptides were found to be very effective in reduction of glioma in in-vitro cultures and also to migrate efficiently towards human glioma cells and prolong the survival of athymic nude mouse bearing intracranial xenografts of human glioma [95]. Here, TNFSF10 is linked to central nervous system cancer.