Adipose tissue acts as an endocrine organ, secreting adipokines that impact energy intake, fat storage, and metabolism such as adiponectin, which is anti-inflammatory, enhances insulin sensitivity, and is inversely associated with obesity, as well as leptin, which is highly correlated with obesity, insulin resistance, and type 2 diabetes [20]. Here, LEP is linked to obesity due to melanocortin 4 receptor deficiency.