Of note, mesenchymal stromal cells (MSCs) from ALL BM have shown atypical production of pro-inflammatory factors whereas disruption of the major cell communication pathway is apparent by detriment of CXCL12 expression and biological function (Geay et al., 2005; Colmone et al., 2008; van den Berk et al., 2014). The gene discussed is CXCL12; the disease is acute lymphoblastic leukemia.