The results shown in Figure 4 confirm that NF-κB mutation in HSPC may perturb HSPC-MSC communication in parallel with the induction of other alterations previously reported in ALL cells, such as the increase of Gfi1 expression (Purizaca et al., 2013) and a pro-inflammatory milieu (Vilchis-Ordoñez et al., 2015). Here, GFI1 is linked to acute lymphoblastic leukemia.