This research team validated the relation between CpG methylation biomarker (DAB2IP CpG1) and poor overall survival in TCGA (a cohort of 318 ccRCC patients) by pyrosequencing quantitative methylation assay in 224 ccRCC patients from multiple Chinese centers (MCHC set) and 239 patients from University of Texas Southwestern Medical Center [39]. This evidence concerns the gene DAB2IP and nonpapillary renal cell carcinoma.