In addition, mutations in SQSTM1 are well known to be associated with familial and/or sporadic Paget disease of bone, ALS, and frontotemporal dementia (FTD) (Fecto et al., 2011, Kwok et al., 2014, Laurin et al., 2002, Le Ber et al., 2013, Miller et al., 2015, Rubino et al., 2012). This evidence concerns the gene SQSTM1 and amyotrophic lateral sclerosis.