TARDBP and Alzheimer disease: In addition to the known hIBM genes, genes encoding for the proteins abnormally accumulated in sIBM muscle are of great interest (Gang et al., 2014), as many of these proteins, such as amyloid-β, hyperphosphorylated tau, p62, and transactive response (TAR) DNA-binding protein-43 (TDP-43), have also been associated with neurodegenerative diseases including Alzheimer's disease (AD), amyotrophic lateral sclerosis (ALS), and Parkinson's disease.