The SQSTM1 p.K238E has also been reported in one sporadic ALS (Rubino et al., 2012) and lies in a tumor necrosis factor receptor–associated factor 6 (TRAF6)–binding site—where p62 interacts with TRAF6, a critical component of the nuclear factor-kappaB pathway in response to multifactors, including proinflammatory cytokines (Fecto et al., 2011). Here, TRAF6 is linked to amyotrophic lateral sclerosis.