NUCLEOLIN and neoplasm: The half‐life of cell surface nucleolin is estimated to be approximately 1 h, whereas that of nuclear nucleolin is greater than 8 h.3, 4 Cell surface nucleolin expression is elevated in rapidly proliferating cells,1, 5 and the overexpression of cell surface nucleolin receptor (NR) has been observed in tumor endothelial cells6 and cell lines derived from human cancers of breast,7 gastric,8 colonic,9 and lung10 origin.