Identification of its essential function in MLL leukaemia had also provided the first evidence of PRMT involvement in human cancer.41 PRMT1 recruitment is required for a subset of MLL (MLL-EEN and MLL-GAS7) and non-MLL (MOZ-TIF2 and AML1-ETO) leukaemia.41, 42, 43 Its inhibition resulted in specific transcriptional and leukaemic suppression in MLL-rearranged and MOZ-TIF2 leukaemia.42 Silence of PRMT1with an short hairpin RNA (shRNA) approach attenuated the level of H4R3me2a and gene expression of HOXA9 and MEIS1, thus leading suppression of leukaemogenesis of MOZ-TIF2 and MLL-GAS7. This evidence concerns the gene KMT2A and leukemia.