KMT2A and acute myeloid leukemia: H3K36me2 demethylase KDM2B that silences p15 expression was sufficient to transform haematopoietic progenitors in vitro, and its depletion significantly impaired HOXA9/MEIS1-driven leukaemogenesis and self-renewal of LSCs.51 H3K9 demethylase JMJD1C was identified as a crucial factor for the maintenance of AML expressing MLL-AF9 in an shRNA functional screen (Figure 1b).