In particular, previous studies demonstrated that CRC invasion and metastasis were stimulated by miR‐21 and miR‐103/107 by down‐regulating tumor suppressors PDCD4, and DAPK and KLF4, respectively, but inhibited by miR‐137 and miR‐30a by down‐regulating oncogenes FMNL2 and PIK3CD, respectively 13, 15, 16, 17. This evidence concerns the gene FMNL2 and neoplasm.