EIF4E and neoplasm: eIF4E overexpression facilitates translation of weak and highly structured mRNAs that typically encode proteins involved in cancer pathology, such as proto-oncoproteins (e.g. cyclin D1, ornithine decarboxylase), angiogenesis factors (e.g. FGF-2, VEGF), and factors related to tumour invasiveness, such as MMP-9 [10], due to the ability of eIF4E to stimulate eIF4A [11].