rs357564 is a missense variant within PTCH1 and rs1529889 is an intronic variant within ADAMST17. rs357564 is predicted to be ‘functional’ by the prediction tool FATHMM (Shihab et al., 2015) and was reported to be associated with oral clefts, basal cell carcinoma and ameloblastoma (Begnini et al., 2010; Carter et al., 2010; Farias et al., 2012). The gene discussed is PTCH1; the disease is ameloblastoma.