NES and experimental autoimmune encephalomyelitis: In mice with myelin oligodendrocyte glycoprotein (MOG)-induced experimental autoimmune encephalomyelitis (EAE), as model of Th1-like antigen-specific chronic inflammatory disease of the central nervous system [41], we found a downregulation of arginase II and concomitant upregulation of arginase I in Nestin+ NSCs of the SVZ at both 25 and 50 days after immunization vs. healthy controls (Fig. 7b).