TARDBP and amyotrophic lateral sclerosis: TDP-43 is a multifunctional RNA binding protein normally localised in the nucleus, however in the majority of ALS cases it is mislocalised from the nucleus to the cytoplasm, where it becomes insoluble, hyperphosphorylated and cleaved (Arai et al., 2006, Hasegawa et al., 2008, Neumann et al., 2006).