TARDBP and amyotrophic lateral sclerosis: This was also demonstrated with pTDP-43 immunofluorescence staining of the NSC-34 cells whereby the only inclusions detected were in cells inoculated with the TDP-43 plasmid and the ALS brain or spinal cord extracts compared to cells transfected with the TDP-43 plasmid and control (Fig. 5C).