TARDBP and amyotrophic lateral sclerosis: These pathological insights, taken together with the discovery that mutations in TDP-43 can cause ALS (Daoud et al., 2009, Kabashi et al., 2008, Sreedharan et al., 2008) and FTLD (Benajiba et al., 2009, Borroni et al., 2009), implicate TDP-43 as a pivotal pathogenic factor both in ALS and FTLD, with these forming an ALS/FTLD disease continuum (Janssens and Van Broeckhoven, 2013).