TARDBP and amyotrophic lateral sclerosis: Pathological reports of phosphorylated TDP-43 (pTDP-43) in ALS post-mortem brain (Brettschneider et al., 2013) and spinal cord (Brettschneider et al., 2014) suggest that TDP-43 pathology could spread via axonal trajectories and synaptic connections as well as non-contiguous spread.