The CDI positivity rate was 2.5-fold higher when methods not detecting toxin versus a recommended algorithm were used (14.1 % vs. 5.4 %, p < 0.001) and 3.5-fold higher for SATT (18.6 vs. 5.4 %, p < 0.001). This evidence concerns the gene SLC1A4 and clostridium difficile infection.