NOTCH1 and acute lymphoblastic leukemia: In addition to the CREBBP and EP300 mutations described above, recurrent non-silent relapse-gained mutations were detected in NOTCH1 (n = 3), KRAS (n = 2) and NT5C2 (n = 2), all of which are known in ALL, as well as SYNE1 (n = 2) and MUC5B (n = 2).