Significant differences in number of putative driver mutations were also observed between the BCP-ALL subtypes, with most driver mutations in patients with HeH and few mutations in patients with the recurrent translocations ETV6-RUNX1, BCR-ABL, or TCF3-PBX1 (p = 1.9 * 10−5, Table 1, Supplementary Figures S9). Here, ETV6 is linked to acute lymphoblastic leukemia.