ERBB2 and breast neoplasm: TP53 mutations, in turn, which are amongst the most frequent mutational events in cancers and can be found in about 37 % of all breast tumors and in up to 80 % of basal-like and ERBB2-enriched tumors [83], have also been demonstrated to cause the metabolic switch towards glycolysis in a Warburg-like manner (Figure 3).