PIK3CA and neoplasm: By identifying appropriate, targeted means of intervening in misbalanced biochemical signaling patterns (e.g. via drugs such as small molecular PI3K-AKT-mTOR inhibitors, glutaminase inhibitors, fulvestrant, metformin, but possibly also by means of glutamine and glucose restriction, specific substrate substitution, antioxidant modification, and general lifestyle changes), one may eventually get down to decreasing tumor rates in genetically predisposed individuals.