BRCA1 and neoplasm: Serum proteomic analyses on BRCA1 mutation carriers have, however, revealed great differences between the protein expression profile of (i) individuals who developed a tumor within the next 3 years, possibly harboring a tumor already at baseline, (ii) those who stayed tumor-free within 7 years of follow-up (until trial closure), and (iii) a cohort of sporadic breast cancer patients; in contrast, accurate discrimination was not possible between healthy controls versus tumor-free BRCA1 mutation carriers [140].