In a tumor setting (Figure 2B), however, cancer cells divert this mechanism towards their own advantage by mimicking a state of energy depletion in surrounding cells even though nutrient supply is ample and constantly triggers the growth-promoting, pro-proliferative PI3K-AKT-mTOR pathway via growth factors such as insulin and insulin-like growth factor 1 (IGF1). Here, IGF1 is linked to neoplasm.