To investigate whether P2Ys play roles in the development of asthma, we used real-time PCR to detect P2Ys expressions in mRNA levels in the lung tissues, and found that the expressions of P2Y1,2,6,12,13 were increased on the 10th day during ovalbumin treatment, especially that of P2Y2 and P2Y6. This evidence concerns the gene P2RY6 and asthma.