To investigate the regulatory function of P2Y6 in mast cells in asthma, mast cells were induced with IL-3 and SCF from primary separation of bone marrow cells, then stimulated with IgE overnight before treatment with UDP and ovalbumin in vitro. Firstly, alteration of the expression of P2Y6 at the mRNA level was detected in mast cells after stimulation with ovalbumin and UDP. Here, KITLG is linked to asthma.