Hypoxia induced ALKBH5 expression in MCF-7, MDA-MB-231, and SUM-159 breast cancer cells, but not in HCC-1954, SUM-149, T47D, or ZR75.1 cells [13], illustrating the heterogeneous nature of the transcriptional response to hypoxia. The gene discussed is ALKBH5; the disease is breast carcinoma.