FTO and breast cancer: However, hypoxia increased the percentage of ALDH+ BCSCs (Figure 1) and expression of pluripotency factors (Figure 2) in all seven breast cancer cells analyzed, including four cell lines in which ALKBH5 expression was not induced by hypoxia (Table 1), suggesting that increased expression of ZNF217 or FTO might contribute to hypoxic induction of the BCSC phenotype.