Adenovirus-5 early region 1A (E1A) exerts its anti-tumor activity through various mechanisms, such as increasing drug sensitivity through the downregulation of HER2/neu [12, 13]; enhancing chemosensitivity by activating the tumor suppressor gene p53 [14]; inducing apoptosis through the activation of p38 [15]; decreasing the levels of miR-520h and the EMT marker TWIST to inhibit metastasis [16]; and increasing chemosensitization by stabilizing FOXO3a [17]. The gene discussed is ERBB2; the disease is neoplasm.