After gefitinib treatment, the tumor volumes of MDA-MB-231/E1A/AXL-injected mice were higher than those of MDA-MB-231/E1A/Ctrl-injected mice, suggesting that downregulation of AXL is essential for E1A-mediated sensitization of EGFR-TKI (Figure 5E). Here, AXL is linked to neoplasm.