The tinnitus group did not display significantly higher mRNA expression of KCC2 gene than the control group in the hippocampus/parahippocampus (0.92 ± 0.11 versus 0.66 ± 0.23, p = 0.143), but the spirulina group had significantly lower mRNA expression of KCC2 gene than the tinnitus group in the parahippocampus/hippocampus (0.48 ± 0.25 versus 0.92 ± 0.11, p = 0.006). This evidence concerns the gene SLC12A5 and Tinnitus.