ERBB2 and ductal breast carcinoma in situ: Briefly, the following variables were associated with increased risk of more than focally positive resection margins in univariate analysis: age <60 years, multifocality, lobular subtype, large tumor size (>2 cm), intermediate- and high-grade, positive ER status, positive Her2 status, angio-invasion, and the presence/extent of a DCIS component.