The median baseline CD4+ count was 461 cells/mm3, 76.1 % had plasma HIV-RNA <50 copies/mL, 63.3 % had significant liver fibrosis (≥F2), 26.2 % had plasma HCV-RNA <500,000 UI/mL, and 45.8 % had the favorable genotype of IL28B polymorphism (AA rs12980275). Here, IFNL3 is linked to Hepatic fibrosis.