Our findings showed that, among Chinese NSCLC patients, carriers of the G allele of OCT2 rs316019 had better toxicity tolerance, whereas carriers of the A allele of MATE1 rs2289669 had poor toxicity tolerance, and carriers of the A allele of ABCC2 rs717620 responded better to platinum-based chemotherapy. This evidence concerns the gene SLC22A2 and non-small cell lung carcinoma.