JUN and scleroderma: CC-930 inhibited UVB-induced phospho-c-Jun in cultured normal human epidermal keratinocytes with IC50 values between 0.1 and 3.0 μM, and it reduced growth factor-induced c-Jun phosphorylation and basal collagen protein expression in human fibroblasts from scleroderma patients at a concentration of 1 μM [28].