For instance, Coelho et al. [20] detected circulating Ang-2 messenger RNA (mRNA) in NSCLC patients’ blood samples (n = 92) and found that a highly circulating Ang-2 mRNA level serving as a significantly unfavorable prognostic factor in NSCLC overall survival is a unique and practical diagnostic tool to determine prognosis in NSCLC. Here, ANGPT2 is linked to non-small cell lung carcinoma.