As showed in the Fig. 2b, all the content of Ang-2 in NSCLC tissues was higher than that in normal tissues, and Ang-2 over-expression was associated with NSCLC (control: pooled OR = 0.87, 95 % CI: 0.56-1.18, P = 0.000). This evidence concerns the gene ANGPT2 and non-small cell lung carcinoma.