Of particular note among the alterations to DC function observed in our model, melanoma-derived TGFβ1 promoted DC secretion of CXCL1, a known macrophage chemoattractant, and enhanced the expression of this chemokine by lung-resident DC in mice bearing lung metastatic melanoma lesions correlated with an increase in M2-like macrophages at this site [79]. The gene discussed is TGFB1; the disease is melanoma.