CD8A and neoplasm: Finally, not only does TGFβ1 contribute to the development of Tregs, but Tregs themselves suppress T cell function through TGFβ1 [120], and blockade of TGFβ1 signaling in CD8+ T cells has been shown to prevent Treg-mediated suppression of anti-tumor immunity in a murine colon carcinoma model [121].