FOXP3 and neoplasm: With regard to CD4+ Tregs, TGFβ1 is known to promote the differentiation of these cells through induction of FOXP3 expression [116], and various tumor-associated cell types that include mesenchymal stem cells, myeloid-derived suppressor cells (MDSC), and DC have all been shown to produce TGFβ1 and induce either the proliferation or differentiation of Tregs [46,117,118,119].