CD4 and neoplasm: For instance, in the EG7 murine thymoma tumor model, membrane-bound TGFβ1 expressed on tumor apoptotic bodies has been shown to inhibit anti-tumor cytotoxic T lymphocyte (CTL) responses through the induction of CD8+ T cell anergy, while at the same time promoting the development of IL-10-producing CD4+ Tregs that inhibit CD8+ T cell proliferation and differentiation into CTL [114].