CD8A and neoplasm: Treatment of mice bearing established mesothelioma tumors with this chimeric “decoy” receptor delayed tumor outgrowth, and this control was associated with improved anti-tumor CD8+ T cell responses; specifically, mice treated with this soluble TGFβRII protein displayed enhanced cytolytic activity in splenic CTL and increased CD8+ T cell infiltration of tumors, whereas no therapeutic benefit was observed in mice depleted of CD8+ T cells prior to treatment [139].