To this point, in a murine model of prostate cancer, conditional knockout of TGFβRII in adoptively-transferred tumor-specific CD8+ T cells resulted in reduced apoptosis, increased proliferation and effector activity and delayed induction of dysfunction in these cells as compared to adoptively-transferred cells in which TGFβ1 signaling was not abrogated [113]. This evidence concerns the gene CD8A and neoplasm.