TGFB1 and neoplasm: Moreover, though it has yet to be explored with respect to TGFβ1’s influence on anti-tumor immune responses, advances in genome editing strategies, such as CRISPR-Cas9 approaches that can be tailored to target gene function at the level of DNA, offer exciting promise for the permanent disruption of genes in specific cells and, therefore, might have an advantage over gene silencing approaches that confer only a temporary diminution in target gene expression.