CD8A and mesothelioma: Neutralization of all three TGFβ isoforms via administration of the 1D11.16 monoclonal antibody has also been shown to significantly enhance the efficacy of a prophylactic irradiated tumor vaccine in the CT26 colorectal cancer model, and like the aforementioned mesothelioma studies, the therapeutic benefit of this treatment was dependent on CD8+ T cells, as well [140].