ESR1 and breast carcinoma: Therefore, the purpose of our project was: (i) to evaluate the specific metabolomic changes induced by each test compound, in relation to the control; (ii) to identify which metabolic modulations are specific to breast cancer cell inhibition or proliferation, by comparing the metabolic profile of cells exposed to IC20 or SC20 of test compounds; and (iii) to identify which modulations are dependent on the estrogen receptors (ER), by comparing the metabolome of MCF-7 cells to the metabolome of MDA-MB-231, exposed to the same test compound, at equivalent concentrations.