Novaro et al. [10] and Tangri et al. [11] did not detect significant associations between polymorphisms within apoE (gene encoding apolipoprotein E), Klotho, β-Klotho, and FGF-23 (genes encoding proteins constituting one of the calcium phosphate homeostasis pathways) genes and mitral annular calcification. This evidence concerns the gene KLB and mitral annular calcification.